Lecture Material

Ogden

Lecture Notes:

Molecular Genetics and Control  Friday January 18

Movie Links

http://vcell.ndsu.nodak.edu/~christjo/vcell/animationSite/lacOperon/movie.htm  - lac operon

http://www.learner.org/channel/courses/biology/units/gmo/images.html  - recombinant DNA and transgenic animals

Alteration of Cell Information  Weds 1/23

Lecture 3 Genetically Engineering Organisms  Fri 1/25

Lecture 4  Monday 1/28 and Weds 1/30

http://highered.mcgraw-hill.com/sites/0072556781/student_view0/chapter11/animation_quiz_5.html

Lecture 5 Genetic Instability  2/1

Cell Growth Summary 2/4

http://azilliad.library.arizona.edu/illiad/pdf/451167.pdf   - Text book chapter on genetically modified organisms

Receptors

Receptors - Engineering

Endocytosis

Riley

Animal cells for pharmaceutical production                                 

            Topic                                                                                           Reading assn

1          Cell and tissue culture                                                                    Palsson Chp 9, 10

2          Pathways and biosynthesis                                                             Reading 2

3          Control and modeling of metabolism                                               Reading 3        Glucose model

4          Stoichiometry and production kinetics                                            Reading 4

5          Pharmaceutical production                                                             Reading 5

6          Immune system function                                                                Reading 6; Palsson, Chp 18.3

7          Optimize cells (Cell line development and screening)                       Reading 7; Palsson, Chp 8

8          Optimize environment (Bioreactors)                                               

9          Pharmaceutical product dosing and storage                                     Reading 9

10        Sterilization of products

Spring break

Tissue engineered devices

11               Overview and introduction to TE approaches                              

12               Tissue organization and dynamics                                              Palsson, Chp 3, 4

13               Interacting cell fate processes                                                    Palsson, Chp 18

14               Stem cells and differentiation                                                    Palsson, Chp 5

15               Time constants and analyses (transport, kinetics)                       Palsson, Chp 12

16                             Bioreactor design and scale up for tissue engineering                  Palsson, Chp 13

17                             Cell separation and isolation                                                      Palsson, Chp 14

18               Biomaterials for tissue engineering                                           Palsson, Chp 15, 16

19               Cellular biomechanics                                                                Biomechanics reading

20                             Mechanotransduction                                

21                             Case study I: connective tissue (a) Normal structure                    Connective tiss reading

22                             Case study I: connective tissue (b) Functional requirements        

23                             Case study I: connective tissue (c) Design of TE replacement      

24                             Case study II: cardiovascular tissue (a) Normal structure             BV reading

25                             Case study II: cardiovascular tissue (b) Functional requirements  

26                             Case study II: cardiovascular tissue (c) Design of TE replacements          

27                             Preservation of cells and tissues                                                 Palsson, Ch 10.6, 19

28                             Clinical implementation                                                              Palsson, Chp 17, 19